The coronavirus disease 2019 (COVID-19) pandemic not only encouraged people to practice good hygiene but also caused behavioral inhibitions and resulted reduction in both endemic and imported infectious diseases.However, the changing patterns of vector-borne diseases under human mobility restrictions remain unclear.Hence, we aimed to investigate th
Multi-omics analyses of glucose metabolic reprogramming in colorectal cancer
BackgroundGlucose metabolic reprogramming (GMR) is a cardinal feature of carcinogenesis and metastasis.However, the underlying mechanisms have not been fully elucidated.The aim of this study was to profile the metabolic signature of primary tumor and circulating tumor cells from metastatic colorectal cancer (mCRC) patients using integrated omics an
Cell-Type-Specific Adaptions in Striatal Medium-Sized Spiny Neurons and Their Roles in Behavioral Responses to Drugs of Abuse
Drug addiction is defined as a compulsive pattern of drug-seeking- and taking- behavior, with recurrent episodes of abstinence and relapse, and a loss of control despite negative consequences.Addictive drugs promote reinforcement by increasing dopamine in the mesocorticolimbic system, which alters excitatory glutamate transmission within the reward